The Protective Effect of Ascorbic Acid and Curcumin on the Chronic Toxicity of Meloxicam on the Testis of Adult Albino Rats

Document Type : Original Research Papers

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Clinical Toxicology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

Abstract

Meloxicam is a type of NSAIDs that has more selectivity on COX-2. Rehashed organization of meloxicam was accounted for to instigate testicular poisonousness, while curcumin and ascorbic corrosive have defensive properties against testicular injury. This examination was expected to explore the poisonous impacts of constant meloxicam organization on the testis, assess the part of oxidative worry in this impact and assess the conceivable defensive impact of curcumin and nutrient C each alone on this harmfulness. For progressive 63 days, grown-up male pale skinned person rodents were designated into 7 gatherings. Gathering A, regulated refined water; bunch B, directed corn oil; bunch C, managed curcumin [100 mg/kg/day intragastric] broke down in corn oil; bunch D, administrated ascorbic corrosive [200 mg/kg/day intragastric] disintegrated in refined water; bunch E, administrated meloxicam [8 mg/kg/day intragastric] broke down in refined water; bunch F, administrated intragastric meloxicam and curcumin in similar past portions and gathering G, administrated intragastric meloxicam and ascorbic corrosive in similar past dosages. Blood and testis tissue tests were gathered for biochemical, histopathological, and ultrastructural assessment. The outcomes uncovered that meloxicam organization in high rehashed dosages prompted a critical lessening in testis weight, sperm boundaries, and cell reinforcement movement of testicular tissue. Plasma testosterone level demonstrated non-critical lessening. Histopathological assessment uncovered rounded degeneration, intercellular vaculaization, interstitial edema and blockage of veins. The ultrastructure assessment uncovered cytoplasmic vacuolations and mitochondrial growing of spermatogenic and sertoli cells. Attendant organization of curcumin or ascorbic corrosive with meloxicam improved these changes. End: The outcomes explained the solid defensive impact of curcumin and ascorbic acids each alone on meloxicam prompted testicular harmfulness in rodents at biochemical, histopathological, and ultrastructural levels.

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