Association of Helicobacter pylori Infection with Portal Hypertensive Gastropathy in Patients with Liver Cirrhosis

Document Type : Original Research Papers

Authors

1 Hepatology, Gastroenterology and Infectious Diseases Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

2 pathology Dept., Faculty of Medicine, Ain Shams Univ., Egypt

3 Nasser Institute of Health, Egypt

Abstract

Portal hypertensive gastropathy(PHG) is a complication of portal hypertension and considered one of the causes of upper gasterointestinal bleeding. Helicobacter pylori as one of the most common pathogenic organism worldwide because it infects 50% of the population all over the world. The role of H. Pylori infection in the development of PHG and its severity is controversal. The aim of this study is to determine the frequency of H. pylori infection in cirrhotic patients with PHG and to find out the possible association of H. pylori infection with PHG severity. This study was carried out on 90 patient with cirrhotic liver, divided into two groups according to prescence or absence of PHG diagnosed by upper endoscopy. H.Pylori infection was significantly more frequent in patients with PHG than patients without PHG. H.Pylori infection was significantly more frequent in patients with sever PHG than patients with mild PHG .Splenomegaly, presence of esophageal varices, gastric varices and H.Pylori infection are independent predictors for PHG presence.

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