Assessment of Neural Precursor Cell Expressed Developmentally Down- Regulated Protein 4 Gene Transcript Variant 3 Expression and Insulin- Like Gross Factor -1 in Keloid Tissue

Alrefai, A.M.; Srour, N.E.; Al-Husseini, N.F.; Abd-Elsayed, M.S.

doi:10.21608/bjas.2020.137172

Assessment of Neural Precursor Cell Expressed Developmentally Down- Regulated Protein 4 Gene Transcript Variant 3 Expression and Insulin- Like Gross Factor -1 in Keloid Tissue

Document Type : Original Research Papers

Authors

¹ Dermatology, Venereology and Andrology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

² Biochemistry and Molecular Biology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

10.21608/bjas.2020.137172

Abstract

Keloids are considered as favorable fibro-proliferative skin tumors developing past the site of the first dermal injury. Neural forerunner cell communicated formatively down-controlled protein 4 (NEDD4) is an E3 ubiquitin ligase catalyst that objectives proteins for ubiquitination. In this investigation, it was intended to survey Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 4 Gene Transcript Variant 3(NEDD4 TV3) and Insulin-like Gross Factor - 1 (IGF-1) in patients with dynamic keloid ≤ 6months length. The examination included 40 patients of keloids and 20 subjects of coordinated age, sex and weight file (BMI). There was critical positive relationship between's NEDD4TV-3 and IGF quality articulation. This information add novel angles to the part of NEDD4 TV3 in the advancement of keloid.

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