The Effect of Bariatric Surgery on GLP-1, Insulin Resistance and Metabolic Parameters in Patients with T2DM

Document Type : Original Research Papers

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Internal Medicine Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

Abstract

The surgical treatment of obesity improves metabolic abnormalities in patients with type 2 diabetes. The aim of this study was to evaluate the immediate and late effect of bariatric surgery on GLP-1, metabolic parameters and insulin resistance in patients with T2DM.Methods fifty patients with T2DM ,obese at levels II and III(BMI more than or equal to 35) were evaluated for BMI, WC, BP, PPGLP-1, fasting plasma glucose, fasting insulin and HOMA-IR before, 1w and 3m after intragastric ballon insertion , RYGBP and SG and evauated for Lipid profile, HbA1C, ALT and AST before and 3m after. The study demonstrated significant increase of PPGLP-1 after RYGBP and SG with better results in RYGBP .No significant change noted after IGB insertion. The metabolic parameters significantly improved in the 3 groups with best results in RYGBP group then SG group followed by IGB group.Our data suggest that the RYGB and SG surgeries,beyond weight loss, induces early beneficial changes in PPGLP-1which favor glycemic control in type 2 diabetes.Keywords RY gastric bypass. SG sleeve gastrectomy.IGB intra gastric ballon.Type 2 diabetes. GLP-1 glucagon like peptide.

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