Role of KruPPel Like Factor (2) in Pathogenesis of Inflammatory Acne

Ibrahim, M.A.; Mohammed, S.A.; Elhabak, D.M.; Abdelaziz, H.T.E.

doi:10.21608/bjas.2020.137421

Role of KruPPel Like Factor (2) in Pathogenesis of Inflammatory Acne

Document Type : Original Research Papers

Authors

¹ Dermatology, Venereology & Andrology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

² Medical Biochemistry &Molecular Biology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

10.21608/bjas.2020.137421

Abstract

Skin break out vulgaris (AV) is a constant inflammatory skin infection that creates around the pilosebaceous contraption. Aggravation assumes a focal part in skin inflammation pathogenesis. The provocative changes advance Propionibacterium skin inflammation (P acnes) abundance through both inborn and versatile insusceptible initiation. It is entrenched that the emission of proinflammatory cytokines, for example, IL-1, IL-8, TNF-α and MMPs adds to the provocative idea of skin break out. KruPPel like factor 2 (KLF2) is end up being a negative controller of aggravation and NFkB movement through a significant raised articulation levels of IL-1, IL-6, TNFα and MMPs. To survey part of KLF2 in pathogenesis of provocative skin break out and its connection to skin inflammation seriousness and example of recuperating of skin inflammation injury, serum level of KLF2 mRNA was estimated in 100 skin inflammation patients and 50 age and sex coordinated sound subjects as control by utilizing quantitative continuous polymerase chain response (qRT-PCR). The mean estimation of KLF2 was lower in skin inflammation bunch than in the benchmark group (P <0.001). The mean estimation of KLF2 was lower in fiery skin break out gathering than in the non-incendiary skin break out gathering (P<0.001). KLF 2 was lower in cases recuperated by scarring than in cases mended by post provocative hyper pigmentation (P=0.016). KLF2 might be a defensive factor against skin inflammation improvement, seriousness and scarring.

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