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Motaleb, M., Othman, A., Ibrahim, I., Moustafa, M. (2021). Preparation and Biological Evaluation of Iodopromazine as a Radiopharmaceutical Model for Brain Imaging. Benha Journal of Applied Sciences, 6(1), 231-236. doi: 10.21608/bjas.2021.169114
M.A. Motaleb; A.M. Othman; I.T. Ibrahim; M.E. Moustafa. "Preparation and Biological Evaluation of Iodopromazine as a Radiopharmaceutical Model for Brain Imaging". Benha Journal of Applied Sciences, 6, 1, 2021, 231-236. doi: 10.21608/bjas.2021.169114
Motaleb, M., Othman, A., Ibrahim, I., Moustafa, M. (2021). 'Preparation and Biological Evaluation of Iodopromazine as a Radiopharmaceutical Model for Brain Imaging', Benha Journal of Applied Sciences, 6(1), pp. 231-236. doi: 10.21608/bjas.2021.169114
Motaleb, M., Othman, A., Ibrahim, I., Moustafa, M. Preparation and Biological Evaluation of Iodopromazine as a Radiopharmaceutical Model for Brain Imaging. Benha Journal of Applied Sciences, 2021; 6(1): 231-236. doi: 10.21608/bjas.2021.169114

Preparation and Biological Evaluation of Iodopromazine as a Radiopharmaceutical Model for Brain Imaging

Article 36, Volume 6, Issue 1, January and February 2021, Page 231-236  XML PDF (544 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2021.169114
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Authors
M.A. Motaleb1; A.M. Othman2; I.T. Ibrahim1; M.E. Moustafa3
1Hot Lab.Center, Atomic Energy Authority,Cairo, Egypt
2Egypt Second Research Reactor, Atomic Energy Authority,Cairo,Egypt
3Chem Dept.,Faculty of Sciences, Benha Univ., Benha, Egypt
Abstract
This study aimed to prepare a novel radiopharmaceutical for the detection of brain disorders at early stages in susceptible patients.Promazine hydrochloride was labeled with 125I by direct electrophilic substitution reaction with high labeling yields of 92.6 ± 3.24 %. The labeling yield and in vitro stability of 125I-promazine were determined by paper electrophoresis, paper chromatography (PC) and High performance liquid chromatography (HPLC). In vitro studies showed that the highest radiochemical yield of 125I-promazine (92.6±3.24%) was stable up to 6 h. Biodistribution studies showed that maximum uptakes of 125I-promazine in the brain of mice was 5.4 ± 0.18 % injected dose/g after 30 min post-injectionwhich is higher than that of 99mTc-HMPAO and 99mTc-ECD (2.25 and 4.7 %, respectively), so this confirms the high specificity and selectivity of this radiotracer for brain and could be used for brain imaging instead of the commercially available 99mTc-HMPAOand 99mTc-ECD.
Keywords
125I-promazine hydrochloride (PMZ); Brain imaging; Electrophilic substitution; Radioiodination
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