Signal transducer and activator of transcription gene polymorphism in type 1autoimmune hepatitis

Alnady, Nazih M.; Behairy, Ola G.; Mohammed, Shuzan A.

doi:10.21608/bjas.2021.169811

Signal transducer and activator of transcription gene polymorphism in type 1autoimmune hepatitis

Document Type : Original Research Papers

Authors

¹ Pediatrics department, Faculty of Medicine, Benha University, Egypt

² Medical Biochemistry department, Faculty of Medicine, Benha University, Egypt

10.21608/bjas.2021.169811

Abstract

Background: Autoimmune hepatitis (AIH) is one of the chronic inflammation types of the liver, characterized by hypergammaglobulinemia and autoantibodies formation. Signal transducer and activator of transcription 4 (STAT4) gene play an important role in dendritic cells, macrophages and activated peripheral blood monocytes. Many previous studies reported the association between STAT4 and some autoimmune diseases, and in a mouse model confirmed the association, STAT4 is an important factor in Th1-dependent liver injury. Aim: to assess the association of a signal transducer and activator of transcription STAT4 gene polymorphism and their interactions with type1 autoimmune hepatitis in children methods: This is across-sectional study, it was performed on 50 patients ages with autoimmune hepatitis from the Pediatric Hepatology Clinic of Benha University Hospitals. All children were subjected to full history taking, physical examination, anthropometric measurements, abdominal examination, serum transaminases, serum bilirubin and serum albumin, PT, PTT, INR, antinuclear antibodies (ANA), anti-smooth muscle antibody (ASMA), antimitochondrial antibody (AMA), anti-liver kidney microsomal antibody (Anti LKM), total IgG levels, hepatitis markers, liver biopsy and genotyping for STAT4 gene.Genotyping of STAT4 gene polymorphism. Conclusion: rs7574865 and rs7582694 in STAT4 gene minor alleles are associated with increased type 1 AIH risk.

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