Evaluation of Serum Levels of Vascular Endothelial Growth Factor (VEGF) in Female Patients with Telogen Effluvium

Document Type : Original Research Papers

Authors

1 Professor of Dermatology, Venereology and Andrology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

2 Assistant Professor of Clinical and Chemical Pathology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

3 Assistant Professor of Dermatology, Venereology and Andrology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

4 (M.B.B.CH), Faculty of Medicine,Tanta Univ., Tanta, Egypt

Abstract

Telogen effluvium is a form of non-scarring diffuse hair loss. It is characterised by premature entrance of a large number of
hairs into telogen phase at one time. In recent years, many growth factors participate in the hair follicle cycle regulation and
promote hair growth. Vascular endothelial growth factor (VEGF) is one of the growth factors stimulating angiogenesis and its
disturbance may lead to telogen effluvium. Evaluation of serum levels of VEGF in female patients with telogen
effluvium.Serum VEGF concentrations were measured in 40 consecutive women with telogen effluvium aged between 18 and
65 years in comparison with 40 women without hair loss using enzyme-linked immunosorbent assay (ELISA). Serum levels of
VEGF were found to be lower in female patients than in healthy controls.Decreased serum levels of VEGF in female patients
than in controls probably reflect the role of VEGF in the pathogenesis of telogen effluvium

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