Assessment of Serum Level of lipocalin2 in Patients with Acne Vulgaris

Sorour, N.E.; Hamed, A.M.; Behery, E.G.; Elsayed, E.M.

doi:10.21608/bjas.2019.187225

Assessment of Serum Level of lipocalin2 in Patients with Acne Vulgaris

Document Type : Original Research Papers

Authors

¹ Assistant Professor of Dermatology, Venereology and Andrology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

² Assistant Professor of Clinical and Chemical Pathology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

³ 3Assistant Professor of Dermatology, Venereology and Andrology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

⁴ (M.B.B.CH), Faculty of Medicine , Zagazig Univ., Zagazig, Egypt

10.21608/bjas.2019.187225

Abstract

Acne vulgaris(AV) is a chronic disease of the pilosebaceous unit which is most common during adolescence. Four factors are believed to play a key role in the development of acne lesions: excess sebum production, disturbed keratinization within the follicle, colonization of the pilosebaceous duct by Propionibacterium acnes,and the release of inflammatory mediators into the skin. Evaluation of serum levels of lipocalin2(LCN2) in acne vulgaris patients.Serum LCN2 concentrations were measured in 30 patients with AV and 30 healthy controls using enzyme-linked immunosorbent assay (ELISA).Serum levels of LCN2 in patients with AV were found to be higher than in healthy controls (p < 0.001). Increased serum LCN2 probably reflect the role of LCN2 in the pathogenesis of AV.