Role of Isocitrate Dehydrogenase 2, Microphthalmia-Associated Transcription Factor and Alpha Melanocyte Stimulating Hormone in Patients with Non-Segmental Generalized Vitiligo

Hussein, K.M.; Sorour, N.E.; Alhusseini, N.F.; Abdou, A.G.; Habashy, A.y.

doi:10.21608/bjas.2021.188825

Role of Isocitrate Dehydrogenase 2, Microphthalmia-Associated Transcription Factor and Alpha Melanocyte Stimulating Hormone in Patients with Non-Segmental Generalized Vitiligo

Document Type : Original Research Papers

Authors

¹ Dermatology and Andrology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

² Medical Biochemistry & Molecular Biology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

³ Pathology, Dept., Faculty of Medicine, Menoufia Univ., Menoufia, Egypt

10.21608/bjas.2021.188825

Abstract

Background: Vitiligo is a complicated, multifaceted condition of the skin. Abnormalities in the surrounding keratinocytes may lead to death of the melanocytes because growth factors are deprived. Ultraviolet band B (NB-UVB) is a successful treatment option particularly in generalised individuals. Objective: The purpose of this research was to assess in lesional skin of vitiligo patients the levels of microphthalmia-associated transcription factor (MITF), alpha melanocyte stimulating hormone and isocitrate dehydrogenase 2 (IDH2) and the influence of NBUVB treatment on them. Methods: 25 patients have been enrolled. They got NBUVB twice weekly for a total of 20 sessions on non-consecutive days. Each patient received skin biopsies from lesional skin before and after treatment. Results: 10% of patients had great clinical response after treatment; 10% showed fair response; 40% showed moderate reactions; 35% showed poor reactions; and 5% exhibited advancing illness. Conclusion: NB-UVB is an effective means of treating vitiligo, by upregulating α MSH, the master regulator of melanogenesis.

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