Hamed, A., .Abdel Khalik, G., Abdel Fatah, M. (2021). Serum level of Alarin in Patients with Androgenetic Alopecia. Benha Journal of Applied Sciences, 6(6), 11-22. doi: 10.21608/bjas.2021.210895
A.M. Hamed; G.M .Abdel Khalik; M.G. Abdel Fatah. "Serum level of Alarin in Patients with Androgenetic Alopecia". Benha Journal of Applied Sciences, 6, 6, 2021, 11-22. doi: 10.21608/bjas.2021.210895
Hamed, A., .Abdel Khalik, G., Abdel Fatah, M. (2021). 'Serum level of Alarin in Patients with Androgenetic Alopecia', Benha Journal of Applied Sciences, 6(6), pp. 11-22. doi: 10.21608/bjas.2021.210895
Hamed, A., .Abdel Khalik, G., Abdel Fatah, M. Serum level of Alarin in Patients with Androgenetic Alopecia. Benha Journal of Applied Sciences, 2021; 6(6): 11-22. doi: 10.21608/bjas.2021.210895
Serum level of Alarin in Patients with Androgenetic Alopecia
Dermatology, Venereology and Andrology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
Abstract
Background: With androgenetic alopecia, hair follicle size decreases dramatically, which may be linked to the death of hair follicle stem cells or progenitor cells in the scalp. To far, scientists believe that AGA is caused by two things: a hereditary predisposition and androgens. In the last several decades, obesity and the metabolic syndrome have spread like wildfire across the globe, posing serious health and economic issues. According to some reports, Alarin is linked to increased caloric intake and weight gain. However, it's unclear if high levels of Alarin in the blood correlate with insulin resistance or the metabolic syndrome. Recent research shows a connection between AGA and cardiovascular disease (CVD), diabetes mellitus and hypertension dating back to the early 1990s (HT). The study's goal was to find out whether there was a link between high levels of serum alarin and androgenic alopecia, as well as obesity and the metabolic syndrome. Methods: The research was carried out at the outpatient clinic of the Benha University Hospitals' Dermatology and Andrology Department in the year 2020. There were 80 people in all, divided into two groups: First, there were 50 patients with androgenic alopecia (Hamilton–Norwood grades I–VII) and 30 age- and sex-matched controls in the first group. Results: In terms of AGA grades, grade 5 was the most common, followed by grades 4 and 2 each (20% each), and finally grade 3. (16 percent ). Grades 1 and 6 were the least common, with only 10% of students achieving them. Those with metabolic syndrome (median=6.38, min-max=0.99-80) had substantially higher levels of alarin (P=0.001) than those without (median=1.08, min-max=0.22-8.37); A significant positive correlation was found between the Alarin level and triglycerides (r = 0.723), cholesterol (r = 0.603), LDL (r = 0.333 & P-value = 0.015), VLDL (r = 0.466) and FBS (r = 0.596 & P-value = 0.001). Neither the alarin level nor HDL, age of illness start, length or systolic blood pressure showed any significant correlations AGA patients had substantially higher median Alarin levels than controls (0.95, IQR; 0.51–1.12) (5.58), IQR; (1.88–10.0), respectively). The P-value was below a threshold of 0.001. P-value was 0.001 because the Alarin level revealed a significant variation among AGA grades; the meidan was 1.05 in grade 1, 1.88 in grade 2, 2.15 in grade 3, 6.38 in grade 4, and 11.0 in lesson 5 and 20.5 in grade 6. Conclusion: Over 70% of adult males and 50% of adult females suffer from androgenetic alopecia (AGA), the most prevalent form of hair loss. This study's findings show that high levels of Alarin are linked to AGA, and that these levels rise as the severity of the illness increases. Additionally, Alarin levels were substantially greater in those with metabolic syndrome and were linked to a higher lipid profile in these patients. According to the results of the present research, another new discovery indicates that Alarin may be able to predict MS and AGA.
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