Serum Intercellular Adhesion Molecule-1 in Patients with Acne Vulgaris

Document Type : Original Research Papers

Authors

1 M.B.B.Ch, Faculty of Medicine- Mansoura University

2 Dermatology, Venereology and Andrology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

3 Clinical and Chemical Pathology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

Abstract

Background: Acne vulgaris is a prevalent skin condition that affects millions of people throughout the globe. Involvement of adolescents and young adults is common, but older people aren't exempt. Inflammation of the facial and trunk pilosbeceous follicles is the hallmark of this condition. An androgen-induced seborrhea, increased ductal hypercornification and the generation of inflammatory mediators by P. acne and P. granulosum trapped in the cornified plug is related with this condition. CD11a and CD11b/CD18 counter-receptors on the surface of immune cells facilitate their transendothelial migration from the circulatory system to inflammatory sites by interacting with ICAM-1 on endothelial cells. Researchers set out to compare the serum levels of Intercellular adhesion molecule-1 (ICAM-1) in acne sufferers and healthy controls in order to determine the protein's contribution to acne development. A total of 30 individuals with AV were included in this research. In addition, a control group of 30 people of the same age and sex was included. A thorough medical history and clinical examination were conducted on each of the subjects investigated. The dermatology outpatient clinic at Benha University Hospitals was used to select all of the patients. They varied in age from seventeen to twenty-seven years old. The study was authorised by the Benha Faculty of Medicine's ethical committee for research involving human participants. Before any samples were collected or tests performed to determine the blood level of Intercellular adhesion molecule-1 (ICAM -1) at the Clinical Pathology Department of Benha University, informed consent was acquired from each subject. Results: There was a statistically significant difference in the levels of sICAM-1 between patients and control groups in this investigation, according to the findings. Patients' sICAM-1 levels were greater than those of the control group which suggests that sICAM-1 may play a role in the disease's development. In teenagers, acne is a common issue and early detection of ICAM-1 levels might aid in the treatment of acne sufferers

Keywords

Main Subjects

Files

Share

How to cite

Statistics