Estimation of Serum Granulysin in Vitiligo patients

Document Type : Original Research Papers

Authors

1 Department of Dermatology & Venereology Faculty of Medicine Tanta University

2 Assistant Professor of Dermatology, Venereology and Andrology Faculty of Medicine Benha University

3 Assistant Professor of Clinical and Chemical Pathology Faculty of Medicine Benha University

4 Professor of Dermatology, Venereology and Andrology Faculty of Medicine Benha University

Abstract

Background: Vitiligo is a chronic immune-mediated inflammatory skin disease, it is a disorder of both the innate and adaptive immune system. Objectives: The aim of this work was to evaluate serum level of granulysin in vitiligo patients . Methods: This case control study included 30 patients suffering from vitiligo . In addition, 20 apparently healthy individuals . Measurement of serum granulysin using enzyme-linked immunosorbent assay was performed in all subjects. Results: When compared to the control group, the vitiligo group had significantly higher serum granulysin levels (P< 0.02). Conclusions: Granulysin levels in the blood may contribute to the pathogenesis of vitiligo. Background: Vitiligo is a chronic immune-mediated inflammatory skin disease, it is a disorder of both the innate and adaptive immune system. Objectives: The aim of this work was to evaluate serum level of granulysin in vitiligo patients . Methods: This case control study included 30 patients suffering from vitiligo . In addition, 20 apparently healthy individuals . Measurement of serum granulysin using enzyme-linked immunosorbent assay was performed in all subjects. Results: When compared to the control group, the vitiligo group had significantly higher serum granulysin levels (P< 0.02). Conclusions: Granulysin levels in the blood may contribute to the pathogenesis of vitiligo.
Vitiligo is an acquired loss of pigmentation following destruction of epidermal melanocytes which leads to appearance of milky white macules and patches that are seen clinically

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