Assessment of Response to Intralesional Vitamin D in Treatment of Warts

Document Type : Original Research Papers

Authors

1 Dermatology, Venereology and Andrology Dept., Fac.,of Medicine, Benha Univ., Egypt

2 Microbiology and Immunology Dept., Fac., of Medicine, Beha Univ., Egypt

Abstract

The human papillomavirus (HPV) causes the common, transient cutaneous condition known as warts. It is infectious, disfiguring, and occasionally benignly koebnerizes. Immunotherapy, which stimulates the immune system, is the most frequent treatment for warts. Even though vitamin D impacts cell proliferation and differentiation, the vitamin D injections effect on wart therapy is unknown. Vitamin D increases the synthesis of antimicrobial peptides, including lymphopiotin and cathelecidin, by upregulating VDRs on immune cells and keratinocytes of the skin. A deficiency in vitamin D may increase the HPV infection incidence by raising the host's susceptibility to HPV penetration and decreasing its capacity to remove the virus.

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