Ginger and Atorvastatin Attenuates Diazinon Induced Nephrotoxicity

Document Type : Original Research Papers

Authors

1 Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt

2 Animal Health Research Institute for Regional Laboratories

3 Department of Pathology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt.

4 Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt.

Abstract

Diazinon (DZ) is an organophosphorus class II pesticide that is broadly used in agricultural fields and household environments. Ginger (GE) and Atorvastatin (AT) have been shown to have potent anti-oxidative, anti-inflammatory and anti-apoptotic properties in some animal models of toxicity. Here, we investigated the protective properties of GE and AT on DZ-induced renal damage in rats. Total of seven rat groups (7 rats/group) received saline solution (control), ginger (GE), Atorvastatin (AT), Diazinon (DZ), DZ/GE, DZ/AT and DZ/GE/AT through gavage once per day for 30 days respectively. Blood were collected and sera were separated for analysis of kidney failure parameters (Urea and Creatinine). Anti-oxidation parameters were also measured in all the kidneys. Histopathology and IHC of cleaved caspase 3 were also performed on the renal tissues of different groups. Our results showed that GE and AT attenuated DZ-induced renal damage by reduction of malondialdehyde (MDA) and apoptotic (cleaved caspase-3) markers and improving the level of antioxidants and histological picture. Overall, the protective effects of GE and ATR on DZ-induced nephrotoxicity was prominent in DZ intoxicated rats co-treated with one or both compounds and this could be attributed to their potent antioxidative, anti-inflammatory and antiapoptotic properties.

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