Ahmed Ali, M., Aly Gad El-Karim, I., S. Behalo, M., A. Negm, N. (2022). Synthesis and antimicrobial evaluation of some Schiff bases and their metal complexes against bacteria and fungi. Benha Journal of Applied Sciences, 7(12), 109-124. doi: 10.21608/bjas.2022.322050
Maram Ahmed Ali; Iman Aly Gad El-Karim; Mohamed S. Behalo; Nabel A. Negm. "Synthesis and antimicrobial evaluation of some Schiff bases and their metal complexes against bacteria and fungi". Benha Journal of Applied Sciences, 7, 12, 2022, 109-124. doi: 10.21608/bjas.2022.322050
Ahmed Ali, M., Aly Gad El-Karim, I., S. Behalo, M., A. Negm, N. (2022). 'Synthesis and antimicrobial evaluation of some Schiff bases and their metal complexes against bacteria and fungi', Benha Journal of Applied Sciences, 7(12), pp. 109-124. doi: 10.21608/bjas.2022.322050
Ahmed Ali, M., Aly Gad El-Karim, I., S. Behalo, M., A. Negm, N. Synthesis and antimicrobial evaluation of some Schiff bases and their metal complexes against bacteria and fungi. Benha Journal of Applied Sciences, 2022; 7(12): 109-124. doi: 10.21608/bjas.2022.322050
Synthesis and antimicrobial evaluation of some Schiff bases and their metal complexes against bacteria and fungi
1Chemistry department, Faculty of Science, Benha University
2Petrochemicals department, Egyptian petroleum research institute
Abstract
Finding novel active compounds to solve the problem of microbial resistance of antibiotic is a matter of urgency. That’s why several drugs were produced from many precursors. Schiff bases are a good base for synthesis several antimicrobial compounds . This work investigates biological activities as cytotoxicity and antimicrobial properties of some Schiff base compounds which synthesized by coupling reaction between two aromatic amines namely: aminoantipyrine, and 4-aminophenol by two aldehydes namely: vanillin and gluteraldehyde. Metal complexes of the obtained four Schiff bases were prepared throughout reaction with copper and ferric ions. FTIR, atomic absorption spectroscopy and 1H-NMR measurements. microbial evaluation of Schiff bases and metal complexes was tested against various microorganisms including: gram +ve and gram -ve bacterial strains utilizing the diameter of inhibition zone, and minimum inhibitory concentration procedures. Showing that the cytotoxic effect of metal complexes is more than the ligand form . Furthermore, Ferric metal complexes exhibited significant inhibition than the copper complexes, which was attributed to the ability of oxidation-reduction tendency of Fe3+ ions than Cu2+. The gram genera of the bacterial strains played a significant role on their resistivity towards the tested antimicrobial compounds, own to the nature of their cellular membranes.