Synthesis and antimicrobial evaluation of some Schiff bases and their metal complexes against bacteria and fungi

Document Type : Original Research Papers

Authors

1 Chemistry department, Faculty of Science, Benha University

2 Petrochemicals department, Egyptian petroleum research institute

Abstract

Finding novel active compounds to solve the problem of microbial resistance of antibiotic is a matter of urgency. That’s why several drugs were produced from many precursors. Schiff bases are a good base for synthesis several antimicrobial compounds . This work investigates  biological activities as cytotoxicity and antimicrobial properties of some Schiff base compounds which synthesized by coupling reaction between two aromatic amines namely: aminoantipyrine, and 4-aminophenol by two aldehydes namely: vanillin and gluteraldehyde. Metal complexes of the obtained four Schiff bases were prepared throughout reaction with copper and ferric ions. FTIR, atomic absorption spectroscopy and  1H-NMR measurements. microbial evaluation of Schiff bases and metal complexes was tested against various microorganisms including: gram +ve and gram -ve  bacterial strains utilizing the diameter of inhibition zone, and minimum inhibitory concentration procedures. Showing that the cytotoxic effect of metal complexes is more than the ligand form . Furthermore, Ferric metal complexes exhibited significant inhibition than the copper complexes, which was attributed to the ability of oxidation-reduction tendency of Fe3+ ions than Cu2+. The gram genera of the bacterial strains played a significant role on their resistivity towards the tested antimicrobial compounds, own to the nature of their cellular membranes.

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Benha Journal of Applied Sciences
Volume 7, Issue 12
December 2022
Pages 109-124

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