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Hussein, K., Sabry, H., Salem, R., Abdelbaky, N., E.Nasr, H. (2023). Peroxisome Proliferator Activated Receptor-Gamma Tissue Expression and Gene Polymorphism in Alopecia Areata in an Egyptian Sample. Benha Journal of Applied Sciences, 8(10), 75-78. doi: 10.21608/bjas.2023.240274.1260
Khaled Hussein; Hanan Sabry; Rehab Salem; Nehal Abdelbaky; Hend E.Nasr. "Peroxisome Proliferator Activated Receptor-Gamma Tissue Expression and Gene Polymorphism in Alopecia Areata in an Egyptian Sample". Benha Journal of Applied Sciences, 8, 10, 2023, 75-78. doi: 10.21608/bjas.2023.240274.1260
Hussein, K., Sabry, H., Salem, R., Abdelbaky, N., E.Nasr, H. (2023). 'Peroxisome Proliferator Activated Receptor-Gamma Tissue Expression and Gene Polymorphism in Alopecia Areata in an Egyptian Sample', Benha Journal of Applied Sciences, 8(10), pp. 75-78. doi: 10.21608/bjas.2023.240274.1260
Hussein, K., Sabry, H., Salem, R., Abdelbaky, N., E.Nasr, H. Peroxisome Proliferator Activated Receptor-Gamma Tissue Expression and Gene Polymorphism in Alopecia Areata in an Egyptian Sample. Benha Journal of Applied Sciences, 2023; 8(10): 75-78. doi: 10.21608/bjas.2023.240274.1260

Peroxisome Proliferator Activated Receptor-Gamma Tissue Expression and Gene Polymorphism in Alopecia Areata in an Egyptian Sample

Article 10, Volume 8, Issue 10, October 2023, Page 75-78  XML PDF (462.66 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2023.240274.1260
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Authors
Khaled Hussein1; Hanan Sabry1; Rehab Salem1; Nehal Abdelbaky email 1; Hend E.Nasr2
1Dermatology, Venereology and Andrology Dept., Faculty of Medicine, Benha University
2Medical Biochemistry and Molecular Biology Dept., Faculty of Medicine, Benha University
Abstract
Background: The The nuclear receptor PPAR- has several roles in controlling metabolic and cellular activities. Recent years have brought increased focus on the roles played by inflammation, lipid metabolism, and immune response regulation in the development of dermatological diseases. PPAR- has several functions in skin biology, and expanding our knowledge of these might help in the treatment of a variety of skin problems. This review aims to evaluate the role of PPAR- in skin diseases. We also discuss its significance in skin biology, from keratinocyte regulation to sebaceous gland function. The use of PPAR- agonists in the treatment of inflammatory skin disorders, viral infections, autoimmune diseases, and hair difficulties is something we want to raise awareness of. PPAR- is emerging as a complicated player in dermatology, and our findings demonstrate its profound impact on skin health and disease. This protein regulates inflammation, lipid metabolism, and the immune response, making it a promising therapeutic target. Psoriasis, atopic dermatitis, and scarring alopecia may all benefit from PPAR- agonists in the future as new therapy alternatives.
Keywords
PPAR-γ; Conditions affecting the skin; swelling; lipid metabolism; the immune response
Main Subjects
Applied and Basic Science.
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