Ibrahim, A., Mostafa, A., Al-Husseini, N., Amr, S. (2023). Intercellular Adhesion Molecule-1 (ICAM-1) gene polymorphism in Patients with Acne Vulgaris. Benha Journal of Applied Sciences, 8(11), 37-40. doi: 10.21608/bjas.2023.244050.1273
Adel Ibrahim; Amany Mostafa; Naglaa Al-Husseini; Suzan Amr. "Intercellular Adhesion Molecule-1 (ICAM-1) gene polymorphism in Patients with Acne Vulgaris". Benha Journal of Applied Sciences, 8, 11, 2023, 37-40. doi: 10.21608/bjas.2023.244050.1273
Ibrahim, A., Mostafa, A., Al-Husseini, N., Amr, S. (2023). 'Intercellular Adhesion Molecule-1 (ICAM-1) gene polymorphism in Patients with Acne Vulgaris', Benha Journal of Applied Sciences, 8(11), pp. 37-40. doi: 10.21608/bjas.2023.244050.1273
Ibrahim, A., Mostafa, A., Al-Husseini, N., Amr, S. Intercellular Adhesion Molecule-1 (ICAM-1) gene polymorphism in Patients with Acne Vulgaris. Benha Journal of Applied Sciences, 2023; 8(11): 37-40. doi: 10.21608/bjas.2023.244050.1273
Intercellular Adhesion Molecule-1 (ICAM-1) gene polymorphism in Patients with Acne Vulgaris
1Dermatology, Venereology and Andrology Dept., Faculty of Medicine, Benha University
2Medical Biochemistry Dept., Faculty of Medicine, Benha University
Abstract
Background: ICAM-Intercellular adhesion molecule-1 (ICAM-1) is a gene that encodes a glycoprotein found on the surface of cells that helps them stick together and respond to immunological stimuli. Several research have looked at whether variations in the ICAM-1 gene have a role in acne vulgaris susceptibility (AV). The purpose of this research was to examine ICAM-1 gene polymorphism in acne vulgaris patients. Methods: Fifty people with AV and 30 people who seemed to be healthy served as controls in this prospective case-control study. Genotyping of ICAM-1 gene polymorphism using PCR necessitated a clinical evaluation and blood sample from all individuals. Results: In regards to the ICAM-1 gene's genotypes and alleles: Everyone, including patients and controls, were genotyped. Two percent of AV patients had the AA genotype, thirty percent had the AG genotype, and fifty-six percent had the GG genotype. Forty percent of healthy controls had the AA genotype, 46.7% the AG genotype, and 13.3% the GG genotype. Acne vulgaris was strongly associated with the GG genotype. In conclusion, ICAM-1 gene polymorphism may increase AV patients' vulnerability.
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