Evaluation of Serum Level of Zinc Alpha 2 Glycoprotein in Male Patients with Androgenetic Alopecia

Document Type : Original Research Papers

Authors

1 Dermatology,venereology and Andrology Dept., Faculty of Medicine, Benha University

2 Assistant Professor of Dermatology, Andrology and Venereology Faculty of Medicine Benha University

3 Clinical and Chemical Pathology Dept., Faculty of Medicine, Benha University

Abstract

Background: Androgenetic Alopecia (AGA) is a prevalent disorder in men that causes hair loss. One potential biomarker for AGA is Zinc Alpha 2 Glycoprotein (ZAG). The objective of this research was to compare the blood levels of insulin resistance and ZAG in male patients with AGA to those in healthy controls. Methods: Twenty healthy volunteers of same age and gender were compared to sixty male AGA patients in this cross-sectional research. The following procedures were carried out: clinical evaluations, laboratory investigations, and ZAG level measurements. Using standard methods, we examined ZAG, lipid profile, fasting blood sugar, insulin, and fasting insulin resistance. Insulin resistance was determined using the HOMA-IR formula. The predictive impact of ZAG in AGA was assessed using multivariate logistic regression analysis. The fasting glucose levels of AGA patients were considerably higher (84±12 mg/dl) than those of controls (78±6 mg/dl), with a p-value of 0.003. In comparison to controls (95.9±10.1 mg/dl, P = 0.012), AGA patients had substantially higher levels of LDL (106.2±25.6 mg/dl). The median ZAG level in AGA patients was 12.1µg/ml, which is substantially higher than the control group's median level of 7.6µg/ml (P = 0.023).

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Benha Journal of Applied Sciences
Volume 8, Issue 12
December 2023
Pages 97-104

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