Serum and Tissue Marker in Keloids and Hyper Trophic Scars : A Comprehensive Review

E. Sorour, Neveen.; I. Azab, Naglaa.; M. El-Habak, Doaa.; O.Abdeltwab, Asmaa.

doi:10.21608/bjas.2024.269680.1327

Serum and Tissue Marker in Keloids and Hyper Trophic Scars : A Comprehensive Review

Document Type : Original Research Papers

Authors

¹ Dermatology, Venereology and Andrology Dept, Faculty of Medicine, Benha University, Benha, Egypt

² Medical Biochemistry and Molecular Biology Dept, Faculty of Medicine, Benha University, Benha, Egypt

10.21608/bjas.2024.269680.1327

Abstract

Background: The irregularities in the healing process may result in hypertrophic scars and keloids, despite the fact that the goal of wound healing is to restore skin integrity with minimum scarring. Patients' quality of life is negatively impacted by these scars, which are defined by abnormal fibroblast activity and excessive collagen synthesis. The purpose of this extensive study is to investigate prolargin's function in keloids and hypertrophic scars, with a particular emphasis on its relationships with variables that contribute to scar formation and its possible use as a biomarker and therapeutic target. Conclusions: Essential for the formation of hypertrophic scars and keloids, prolargin has a substantial effect on collagen synthesis and fibroblast activity. It seems to be an important regulator of scarring based on its interactions with the immune system and the extracellular matrix. There are encouraging treatment options for reducing pathological scarring that include prolargin, due to its ability to inhibit pathways in the complement system and improve skin layer adhesion. To find out how prolargin contributes to scar development and how to treat them effectively, more research is required.

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