Klotho G-395A Gene Polymorphism: Impact on Progression of End-Stage Renal Disease and Development of Cardiovascular Complications in Children on Dialysis

M. Ezzat, Ahmed; R. Soliman, Doaa; A. Elsayed, Inas; Afifi, Wesam El-Menshawy; E. Afifi, Mona; S. Abd El Haleem, Ahmed

doi:10.21608/bjas.2024.274459.1344

Klotho G-395A Gene Polymorphism: Impact on Progression of End-Stage Renal Disease and Development of Cardiovascular Complications in Children on Dialysis

Document Type : Original Research Papers

Authors

¹ Pediatrics Department, Faculty of Medicine, Benha University

² Assistant Professor of Pediatrics and Neonatology Faculty of Medicine &ndash; Benha University

10.21608/bjas.2024.274459.1344

Abstract

Background: at In recent years, many indicators have been identified that may predict the likelihood of chronic kidney disease in children who already have certain risk factors. But it's still not easy to accurately measure danger. Goal: This research set out to examine the relationship between cardiovascular problems in juvenile patients on hemodialysis for end-stage renal illness and klotho gene polymorphisms (G-395A). Procedures and Materials: Fifty children participated in the case control study; twenty were on maintenance hemodialysis for end-stage renal disease, ten were on conservative therapy for chronic kidney disease, and ten were healthy controls. All forty kids were genotyped for Klotho G-395A and evaluated for clinical and echographic variants. Findings: Compared to control children, children with chronic kidney disease (both conservative and hemodialysis patients) had much higher frequencies of the GA + AA genotype. The frequencies of the G and A alleles were also significantly different. When looking at the two groups side by side, we can see that the GG and GA+AA frequencies were significantly different between the control and hemodialysis groups, but not between the conservative and hemodialysis groups. On the other hand, the AA genotype frequency was significantly different between the conservative and control groups, as well as between the hemodialysis and control groups. In conclusion, CKD risk factors increased the likelihood of development in children carrying the AA or GA genes, which are examples of wild genes.

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