Pathogenesis of Acne Vulgaris in Adolescence

M. Hamed, Ahmed; Y. Habashy, Amal; A. El Abd, Omnia; E. Ahmed, Nashwa

doi:10.21608/bjas.2024.279844.1376

Pathogenesis of Acne Vulgaris in Adolescence

Document Type : Original Research Papers

Authors

¹ Dermatology, Venerology and Andrology Department, Faculty of Medicine, Benha University

² Biochemistry and Molecular Biology Department, Faculty of Medicine, Benha University

10.21608/bjas.2024.279844.1376

Abstract

Objectives: Describe the pathophysiology of acne vulgaris and talk about how androgens contribute to the onset of the condition throughout puberty. Background: Acne is a skin ailment that often affects children and teenagers. It seems that the condition is triggered by an increase in the amounts of circulating androgens that originate from the adrenal glands and the testes. Research Methods: We scoured the Medline databases (Pub Med and Medscape) for research that elucidate the pathophysiology of acne vulgaris and address the part played by androgens in the onset of the condition in adolescents up to the year 2023. Research Prioritization: The inclusion of all research was determined by separate evaluations. Inclusion was contingent upon them meeting the following requirements: 1. Presented in an English language format. 2. Publicated in publications that undergo a rigorous peer review process. 3. Explain the process by which acne vulgaris develops and talk about how androgens play a part in this adolescent skin condition. Data Extraction: Studies were omitted from consideration if they failed to meet the inclusion criteria. The study's quality was evaluated based on a number of aspects, such as the following: the availability of sufficient information; the clarity of evaluation criteria; and the acquisition of ethical permission. For our concerned research outcomes, data were independently extracted from all qualifying studies utilizing a data collecting form. Conclusions: Acne is a problem that mostly affects children and teenagers, and it seems that the illness is triggered by elevated amounts of circulating androgens that originate from the adrenal glands and the testicles. Acne pathogenesis involves a series of events that occur in a relatively consecutive order: retained hyperkeratosis, hyperplasia of the sebaceous glands and increased sebum production, follicle colonization by Propionibacterium acnes, and inflammation around the follicles.

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