Secondary metabolites from marine fungi as anticandidia

N. Wesa, Samuel; Hassan, Mervat Gameel; A. AboElmaaty, Sabah; A Hamed, Ahmed; Elawady, Mohamed E.; G. Hassan, Mervat; E. Elawady, Mohamed

doi:10.21608/bjas.2024.270362.1336

Secondary metabolites from marine fungi as anticandidia

Document Type : Original Research Papers

Authors

¹ Botany and Microbiology Department, faculty of science, Benha University, Benha, Egypt

² Microbiology and Botany, Science , Benha University, Benha Egypt

³ Microbial Chemistry department, National Research Centre, El Buhouth St. 33, Cairo, Egypt

⁴ Microbial Biotechnology Department , National Research Centre , El Buhouth St. 33, Cairo 12622, Egypt

⁵ Microbial Biotechnology Department, National Research Centre, El Buhouth St. 33, Cairo, Egypt

10.21608/bjas.2024.270362.1336

Abstract

Background: Most fungal pathogen-induced infections in humans are caused by species of Candida. Members of these species include Candida albicans, which is the most common cause of opportunistic infections. Purpose: to determine whether bioactive compounds isolated from thirteen different fungal strains have anticandida properties against a variety of Candida isolates obtained from urine and vaginal samples. The findings demonstrate a marked variation in the inhibitory responses amongst various strains of Candida, indicating a complex interaction between fungal strains and their bioactive compounds. There were clear strain-specific variations, with some fungal strains showing strong efficacy and others showing little to no inhibitory effects. Interestingly, Fungal Strain 8 continuously exhibited strong inhibitory responses, highlighting the significant influence of particular fungal strains. Different Candida isolates had varying levels of sensitivity to bioactive compounds, highlighting the need for specialized antifungal treatments. Clinical relevance can be drawn from the observed diversity in anticandida activity, which points to possible directions for the development of targeted antifungal drugs. Subsequent investigations may delve into fundamental mechanisms, pinpoint pivotal bioactive compounds, and facilitate the advancement of innovative antifungal medication discovery. Conclusion: this research provides significant understanding of the intricate dynamics of anticandida activity, laying the groundwork for future developments in specialized treatments to combat Candida infections.

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