Exploring Marine Fungal Crude Extracts for Antidiabetic Potential

Document Type : Original Research Papers

Authors

1 Microbiology,Alazhar university,Cairo

2 Botany and Mirobiology,Faculty of science, Benha University, Egypt

3 plant and Mirobiology,Faculty of science, Mansoura University, Egypt

4 Mirobial Biotechnology, National Rsarh Center. Egypt

5 Botany and Mirobiology,Faculty of science, Benha University, Benha, Egypt

Abstract

This study focused on the exploration of antidiabetic potential within marine fungal communities collected from diverse locations in Hurghada. Various fungi were isolated from Sponge 1, 2, and Sea Grass, exhibiting distinct morphologies. Notable isolates included s289 (white-gray) from Sponge 2, s313 (black) from Sponge 1, and s213 (black) from Sponge 2. Small-scale fermentation and extraction processes were employed to obtain crude extracts, concentrating bioactive secondary metabolites. Evaluation of antidiabetic activity through α-glucosidase inhibition revealed distinct inhibitory potency levels among the extracts. Notably, s313 displayed potent activity (IC50: 0.505 mg/ml), suggesting promising antidiabetic potential. Moderately inhibitory activities were observed for s289 (IC50: 0.972 mg/ml) and s213 (IC50: 0.617 mg/ml). The comparison with the reference drug Acarbose (IC50: 0.375 mg/ml) highlighted the competitive nature of the fungal extracts. This study underscores the diverse bioactivity of marine fungal crude extracts and emphasizes their potential as alternative or complementary antidiabetic agents, encouraging further exploration of natural sources for effective treatments.

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Benha Journal of Applied Sciences
Volume 9, Issue 1
January 2024
Pages 23-28

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