Beta 1 Integrin in Hair Follicles of Patients with Androgenetic Alopecia

Document Type : Original Research Papers

Authors

1 Assistant Professor of Dermatology, Venereology and Andrology Faculty of Medicine- Benha University

2 Assistant Professor of Dermatology, Venereology and Andrology Faculty of Medicine - Benha University

3 Assistant Professor of Pathology Faculty of Medicine- Benha University

4 M.B.B. Ch Faculty of Medicine – Benha University -2014

Abstract

Background: Androgenetic alopecia (AGA) is a hereditary hair loss illness characterized by a slow but steady transition from terminal to indeterminate and, eventually, vellus hairs. The process by which cells adhere to both the extracellular matrix and other cells is mediated by heterodimeric transmembrane proteins called integrins, which include of an α and a β component. The purpose of this paper is to examine the association between the severity of AGA etiopathogenesis and the tissue expression of β1 integrin, as well as to evaluate its participation in this process. Results: Beta 1 integrin has the potential to be an indicator of AGA severity and a key player in the disease's etiology. Background: Androgenetic alopecia (AGA) is a hereditary hair loss illness characterized by a slow but steady transition from terminal to indeterminate and, eventually, vellus hairs. The process by which cells adhere to both the extracellular matrix and other cells is mediated by heterodimeric transmembrane proteins called integrins, which include of an α and a β component. The purpose of this paper is to examine the association between the severity of AGA etiopathogenesis and the tissue expression of β1 integrin, as well as to evaluate its participation in this process. Results: Beta 1 integrin has the potential to be an indicator of AGA severity and a key player in the disease's etiology.

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