A Study of The Association Between Cysteinyl Aspartate Protease -5 (CASP5) Gene Expression & Plasma Level and The Risk of Rheumatoid Arthritis (RA)

Document Type : Original Research Papers

Authors

1 Professor of Clinical & Chemical Pathology Faculty of Medicine - Benha University

2 Assistant Professor of Clinical & Chemical Pathology Faculty of Medicine - Benha University

3 Assistant ProfessorRheumatology and Rehabilitation and Physical Medicine Faculty of medicine, Benha University

4 (M.Sc.)

Abstract

Background:Rheumatoid The prevalence of arthritis (RA), a systemic inflammatory illness that worsens over time, ranges from 0.2% to 1.1% worldwide. An essential component of the caspase family, the caspase-5 (CASP5) gene is involved in the regulation of immune response and cell death. The correlation between CASP5 plasma levels and CASP5 expression gene levels in B cells and T cells PBMCs implies that CASP5 may represent a new risk biomarker for RA. In a case-control study with 80 participants, researchers discovered that mild activity accounted for 15.0% of RA cases, moderate activity for 30.0%, and high activity for 55.0%. In comparison to the control group, RA patients were found to have a considerably higher ESR and a lower Hb. Sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy were all improved when CASP5 gene expression levels and CASP5 plasma levels were matched. Levels of CASP5 gene expression and plasma CASP5 levels were both shown to be strongly associated with RA susceptibility when logistic regression analysis was used to forecast RA vulnerability.one, two, three (1)

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Benha Journal of Applied Sciences
Volume 9, Issue 9
September 2024
Pages 91-102

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