The Interplay of Acanthosis Nigricans, Obesity, and Cardiovascular Health in Pediatric Patients

Mohamed Abdallah Shouman, Ghada; Hasan Sabry, Hanan; Mohamed Abd El-Khalik, Ghada; Osama Abd El-Ghafar, Amira; Ibrahim Allam, Hager

doi:10.21608/bjas.2024.328920.1524

The Interplay of Acanthosis Nigricans, Obesity, and Cardiovascular Health in Pediatric Patients

Document Type : Original Research Papers

Authors

¹ M.B.B.Ch, Faculty of Medicine - Zagazig University-2012

² Head of department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Egypt

³ Lecturer of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Egypt

⁴ Lecturer of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Egypt

⁵ Lecturer of Cardiology, Faculty of Medicine, Benha University, Egypt

10.21608/bjas.2024.328920.1524

Abstract

Background: One skin condition that often goes hand in hand with obesity and insulin resistance is acanthosis nigricans (AN), which manifests as velvety, darker skin in intertriginous regions. This study delves into the correlation between anorexia nervosa (AN), obesity, and cardiovascular health, specifically looking at NT-proBNP levels in children.Aim: With a focus on NT-proBNP as a possible biomarker for heart health in juvenile patients, this study seeks to investigate the relationship between acanthosis nigricans, obesity, and cardiovascular function.
Pathophysiology, categorization, diagnostic methods, and the relationship between AN, obesity, and insulin resistance are all included in this review. It delves further into the intricate web of connections between AN, obesity, and CVD, drawing attention to the part played by adipokines and metabolic syndrome. Additionally, the study explores the use of NT-proBNP in evaluating heart function, with a focus on metabolic diseases and obesity.
Conclusion: One of the risk factors for cardiovascular disease, acanthosis nigricans is a visual indicator of metabolic abnormalities, especially obesity and insulin resistance. Obesity may affect the levels of NT-proBNP, yet this biomarker shows promise as a tool for evaluating heart function in children with AN. We still don't know enough about the complex interplay between AN, obesity, and children's cardiovascular health for NT-proBNP to have any practical use in clinical practice with this group of patients.

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