Role of miRNA-146a and miRNA-125b in Helicobacter Pylori Infection in Children

Mohamed, Nashwa F.; Behairy, Ola G.A.; EL-Defrawy, Manal S.; El- Sayed, Mona M.; Alhusseini, Naglaa F.

doi:10.21608/bjas.2024.329294.1525

Role of miRNA-146a and miRNA-125b in Helicobacter Pylori Infection in Children

Document Type : Review Articles

Authors

¹ Pediatrics Department, Faculty of Medicine, Benha University, Benha, Egypt.

² Pediatrics Department, Shibin El-Qanater Hospital, Al-Qalyubia, Egypt.

³ Medical Biochemistry and Molecular Biology Faculty of Medicine, Benha University, Benha, Egypt

10.21608/bjas.2024.329294.1525

Abstract

Background: Helicobacter pylori (H. pylori) infection is significant global health concern, particularly in pediatric populations where it can lead to chronic gastritis, peptic ulcers, and increased risk of gastric malignancies. MicroRNAs (miRNAs), specifically miRNA-146a and miRNA-125b, are emerging as crucial regulators of immune responses and inflammation in various diseases, including H. pylori infection. Understanding roles of miRNAs could provide novel insights into pathogenesis and management of H. pylori-related diseases in children.
Objective: narrative review aims to explore roles of miRNA-146a and miRNA-125b in context of H. pylori infection in children, with focus on their potential as biomarkers and therapeutic targets.
Methods: comprehensive review of current literature was conducted, analyzing studies investigate molecular mechanisms of miRNA-146a and miRNA-125b and their involvement in immune regulation during H. pylori infection. review also examines implications of miRNAs for disease progression, severity, and therapeutic strategies in pediatric patients.
Conclusion: miRNA-146a and miRNA-125b play critical roles in modulating immune response to H. pylori infection in children, potentially influencing disease severity and outcomes. However, further research is necessary to fully elucidate their roles and develop effective clinical applications.

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