Role of miR-7 as Potential Biomarker for Colorectal Cancer

Document Type : Original Research Papers

Authors

1 M.Sc Department of Medical Biochemistry & Molecular Biolog - (Faculty of Medicine – Benha University

2 Professor of Medical Biochemistry & Molecular Biolog - Benha Faculty of Medicine - Benha University

3 Assist. Professor of Medical Biochemistry & Molecular Biology - Benha Faculty of Medicine – Benha University

4 Assist. Professor of General Surgery - Benha Faculty of Medicine – Benha University

5 Lecturer of Medical Biochemistry & Molecular Biology - Benha Faculty of Medicine – Benha University

Abstract

Two-thirds of colorectal cancers (CRCs) occur in more developed parts of the world, making it the third most frequent cancer globally after lung and breast cancers. All racial and ethnic groups are affected by CRC, which primarily affects those 50 years of age and older. This condition may arise as a result of a variety of circumstances, including environmental and hereditary ones. The majority of cases are discovered until after symptoms appear, despite the fact that colorectal cancer screening lowers the frequency of diagnosis at advanced stages. MicroRNAs (miRNA), which are frequently dysregulated in cancer, are crucial for regulating gene expression. Since miR-7 affects the expression of several oncogenes, revealing how miR-7 activity is regulated will probably help us better understand the causes of different types of cancer. The purpose of this study was to look at how miR-7 affects colorectal cancer. We discovered a strong correlation between CRC and miR-7.
miRNA-7 is circulating as a possible non-invasive biomarker for several illnesses and disorders, including colorectal cancer. This study sought to determine whether microRNA-7 may be used as a diagnostic tool for colorectal cancer.

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Benha Journal of Applied Sciences
Volume 9, Issue 11
November 2024
Pages 73-77

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