Serum Interleukin 40 and Transforming Growth Factor -β in patients with inflammatory acne: a narrative review

Document Type : Original Research Papers

Authors

1 Assistant Professor of Dermatology & Venereology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt

2 Professor of Dermatology & Venereology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt

3 M.B.B.Ch, Faculty of Medicine, Benha University, 2017, Benha, Egypt

4 Assistant Professor of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha, Egypt

Abstract

Background: Numerous pathogenic factors contribute to the inflammatory nature of acne vulgaris, a prevalent skin condition. Acne lesion genesis and the function of skin immune cells are poorly understood.
Objectives: The objective of the research was to gain insight into the immunologic alterations that occur during acne progression by measuring serum IL-40 and TGF-β levels.
Data Sources: Through the use of Medline databases (Pub Med and Medscape) and research on the function of IL-40 and TGF-β in acne sufferers up to the year 2024.
Study Selection: The inclusion of all research was determined by separate evaluations. They were considered for inclusion if they met the following requirements: 1. The publication is in English. Second, they are published in publications that undergo a peer review process.3. Evaluate the function of IL-40 or TGFβ in individuals suffering from acne vulgaris.
Data Extraction: Research was not considered for inclusion if it did not meet certain requirements. Ethical permission, clearly stated eligibility criteria, suitable controls, sufficient information, and well-defined evaluation methods were all factors in determining the study's quality. For our concerned research outcomes, data were independently extracted from all qualifying studies utilizing a data collecting form.
Conclusions: TGF-β and IL-40 have a crucial role in the development of acne vulgaris and may serve as a predictor of acne.

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Benha Journal of Applied Sciences
Volume 9, Issue 12
December 2024
Pages 59-62

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