Association between Interleukin-32 Gene Olymorphism (rs4786370) and the Susceptibility to Preeclampsia in Egyptian Pregnant Women

Elsaeed, Ibrahim Mohamed; Ameen, Seham Gouda; Amer, Wagdy Megahed; Khashaba, Rana Atef; Yaseen, Samar Esam

doi:10.21608/bjas.2025.345604.1556

Association between Interleukin-32 Gene Olymorphism (rs4786370) and the Susceptibility to Preeclampsia in Egyptian Pregnant Women

Document Type : Original Research Papers

Authors

¹ Professor of Clinical and Chemical Pathology Faculty of Medicine, Benha University

² Assistant Professor of Clinical and Chemical Pathology Faculty of Medicine, Benha University

³ Assistant Professor of Obstetrics and Gynecology Faculty of Medicine, Benha University

⁴ (MSc. – Benha University, 2019) Assistant Lecturer of Clinical and Chemical Pathology Faculty of Medicine – Benha University

10.21608/bjas.2025.345604.1556

Abstract

Background: Preeclampsia (PE) is an organ dysfunction issue unique to pregnancy that manifests as in hypertension and proteinuria.Due to its participation in several important biological processes, interleukin-32 (IL-32), a proinflammatory cytokine mostly expressed by natural killer (NK) cells, monocytes, epithelial cell lines, and T-cells, has become famous. The purpose of this literature study is to discover if there is a correlation between the Interleukin-32 gene polymorphism (rs4786370) and the risk of preeclampsia in pregnant women from Egypt. In conclusion, pregnant women in Egypt may be able to use the IL-32 rs4786370 gene polymorphism as a marker to estimate their risk of preeclampsia.Preeclampsia (PE) is an organ dysfunction issue unique to pregnancy that manifests as in hypertension and proteinuria.Due to its participation in several important biological processes, interleukin-32 (IL-32), a proinflammatory cytokine mostly expressed by natural killer (NK) cells, monocytes, epithelial cell lines, and T-cells, has become famous. The purpose of this literature study is to discover if there is a correlation between the Interleukin-32 gene polymorphism (rs4786370) and the risk of preeclampsia in pregnant women from Egypt. In conclusion, pregnant women in Egypt may be able to use the IL-32 rs4786370 gene polymorphism as a marker to estimate their risk of preeclampsia.

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