Immunohistochemical Markers of Melanocyte Content in Vitiligo Skin.

Document Type : Review Articles

Authors

1 Dermatology, Venereology and Andrology Departmnt, Faculty of Medicine, Benha University

2 DERMATOLOGY, venerology and Andrology Department Faculty of Medicine-Benha University

3 Assistant Professor of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University

4 Department of Pathology, Faculty of Medicine, Menoufia University

Abstract

Abstract
Background: Vitiligo is a common acquired pigmentary skin condition, affecting people all around the world. lesions of vitiligo develop due to loss of functional melanocytes in the affected skin, leading to a decrease in the amount of melanin pigment. Even after depigmentation process has occurred, questions about the existence of remaining melanocytes in skin and the best ways to identify them persist. Objectives: This paper aims to detect if the Melan-A also known as MART-1, is a Melanoma Antigen Recognized by T cells - 1 marker and Human Melanoma Black-45 (HMB-45) marker may be used to diagnose vitiligo by detecting melanocytes in vitiligo skin. Conclusions: Both the detection of melanocytes in vitiligo patients' skin and the estimation of melanocyte concentration may be aided by the use of Melan-A and HMB-45 markers. Since there has not been a single identified marker that stains melanocytes with maximum sensitivity and specificity, immunohistochemical markers are commonly used in combination.

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Benha Journal of Applied Sciences
Volume 10, Issue 1 - Serial Number 1
Medical and Health Sciences:
January 2025
Pages 59-65

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