Role of Serum Heat Shock Protein 70 (HSP70) in Patients with Alopecia Areata

Document Type : Review Articles

Authors

1 Dermatology, Venerology and Andrology Department, Faculty of Medicine, Benha University

2 Professor of Dermatology, Venereology and Andrology Faculty of Medicine - Benha University

3 Assistant Professor of Dermatology, Venereology and Andrology Faculty of Medicine - Benha University

4 Lecturer of Clinical and Chemical Pathology Faculty of Medicine, Benha University

5 Lecturer of Audiology, ENT Department Faculty of Medicine, Benha University

Abstract

An immune-mediated assault on hair follicles causes non-scarring hair loss in alopecia areata (AA), a common autoimmune condition. Numerous autoimmune and inflammatory diseases have been linked to heat shock protein 70 (HSP70), a molecular chaperone involved in immune regulation and cellular stress response. Recent research has also shown a possible connection between sensorineural hearing loss (SNHL) and autoimmune illnesses, maybe as a result of similar pathogenic pathways involving inflammation and immunological dysregulation. Goals: HSP70 serum levels are being investigated for their possible involvement in the etiopathogenesis of AA, their relationship to the severity of AA, and any possible connections to audiological problems in these individuals.
Data Sources: Medline databases (Pub Med and Medscape) were searched and analyzed in order to find research that examined the function of HSP70 in AA that were published up to 2024. Study Selection: Every study was evaluated for inclusion on its own. If they met the following requirements, they were accepted: 1. English-language writing and publication. 2. Printed in journals with peer review. 3. Examine the involvement of HSP70 in AA. Data Extraction: Studies were eliminated if they failed to meet the requirements for inclusion. Whether ethical permission was obtained, eligibility requirements were stated, suitable controls were used, sufficient information was provided, and evaluation metrics were clearly established were all taken into consideration when evaluating the quality of the study.

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Benha Journal of Applied Sciences
Volume 10, Issue 1 - Serial Number 1
Medical and Health Sciences:
January 2025
Pages 75-78

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