Assessment of serum level of spexin in psoriasis vulgaris

Document Type : Original Research Papers

Authors

1 Dermatology, Venerology and Andrology Department, Faculty of Medicine, Benha University, Benha, Egypt

2 Clinical and Chemical Pathology Department, Faculty of Medicine, Benha University, Benha, Egypt

Abstract

Background: Psoriasis vulgaris is a chronic inflammatory skin disease that manifests mainly as raised, erythematous, and scaly plaques. Psoriasis is associated with increased risk of several comorbidities, such as Crohn's disease, malignancy, obesity, and cardiovascular diseases. The relationship between psoriasis vulgaris and metabolic syndrome (MetS) has been a subject of increasing interest in recent years.
Objective: This article aims to review the link between metabolic syndrome and psoriasis vulgaris and its correlation with psoriasis severity.
Data Sources: The literatures on the causes, pathogenesis, clinical pictures of psoriasis vulgaris, discuss role of metabolic syndrome in patients with psoriasis vulgaris and its correlation with the disease’s severity decline up to 2024 was sourced via a search of the Medline databases (Pub Med and Medscape).
Data Extraction: If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment factors included whether ethical approval was gained, eligibility criteria specified, appropriate controls, and adequate information and well-defined evaluation measures. Data from each eligible study were independently abstracted using a data collection form to capture information related to our concerned study outcomes.
Conclusions: Both psoriasis vulgaris and MetS are associated with hormonal changes, insulin resistance, oxidative stress and chronic inflammation. Studies have shown that individuals with MetS are more likely to have severe psoriasis.

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Benha Journal of Applied Sciences
Volume 10, Issue 1 - Serial Number 1
Medical and Health Sciences:
January 2025
Pages 91-95

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