Document Type : Original Research Papers
Authors
1
Assistant Professor of Pediatrics, Faculty of Medicine, Benha University, Benha, Egypt
2
Pediatric Department, Faculty of Medicine, Benha University, Benha, Egypt
3
Professor of Pediatrics, Faculty of Medicine, Banha University, Benha, Egypt
4
Lecturer of clinical and chemical pathology, Faculty of Medicine, Benha University, Benha, Egypt
Abstract
Background: Worldwide, neonatal hypoxia is a major contributor to illness and death. A key result of prenatal hypoxia is hypoxic-ischemic encephalopathy (HIE), which is often associated with cardiac dysfunction.
Objective: The purpose of this research is to determine if there is a connection between cTnT levels and newborn outcomes, HIE stages, the need of inotropic support, and asphyxiated neonates.
Methods: Perinatal hypoxia was the subject of a prospective observational research including newborns. The levels of cTnT were assessed throughout the first twenty-four hours of life. By using the Sarnat staging technique, the severity of HIE was categorised. At discharge, we evaluated the neonate's neurodevelopmental state and noted their inotrope needs. In order to find connections, statistical analysis used regression.
Results: Stage III newborns with severe HIE had elevated cTnT levels compared to stage I and stage II neonates with mild or moderate HIE (p < 0.001). The findings showed a strong positive relationship (r = 0.76, p < 0.001) between cTnT levels and inotrope needs. There was a correlation between high cTnT levels and unfavourable outcomes, such as death and extended hospital stays (OR = 3.5, CI: 1.8-6.8, p = 0.002).
Conclusion: The degree of cardiac damage in newborns exposed to hypoxia may be reliably assessed by measuring cTnT levels. They have a high degree of correlation with newborn outcomes, inotropic support requirements, and HIE stages. Optimal care options for neonates with perinatal hypoxia may be achieved by early detection of high cTnT levels, which may help in risk categorisation.
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