Document Type : Original Research Papers
Authors
1
Botany and Microbiology Department, Faculty of Science, Benha University, Benha 33516, Egypt
2
Sherbin, Mansoura, Egypt
3
Drug Radiation Research Department, Egyptian Atomic Energy authority
4
Professor of Botany and Microbiology Department , Faculty of Science, Benha University
5
Applied Medical Chemistry Medical Research Institute Alexandria university
6
Main laboratories for Egyptian Army
7
Botany and Microbiology Department, Faculty of Science, Benha University, Egypt
Abstract
Background:Zinc oxide silica nanoparticles (ZnO NPs) have drawn interest due to their distinct physical, chemical, and biological characteristics, which make them attractive options for antibacterial and anticancer uses. Hazardous materials are frequently used in traditional chemical synthesis techniques, which makes greener, more sustainable alternatives necessary. Using Alteromonas sp., a bacteria known for its metabolic capabilities, this work investigates the synthesis of ZnO NPs and assesses their characterisation, antimicrobial, and anticancer characteristics.. Methods: (ZnO NPs) were synthesized by incubating Alteromonas sp with zinc acetate and sodium silicate under controlled conditions. The resulting nanoparticles were purified and characterized using UV-Vis, TEM, XRD, DLS, and FTIR. Antimicrobial activity was assessed against bacterial pathogens, while anticancer activity was evaluated using cancer cell lines. Results: The synthesized (ZnO NPs) exhibited significant antimicrobial activity against various pathogens and demonstrated promising anticancer effects by inducing oxidative stress and apoptosis in cancer cell lines. Conclusion: Using Alteromonas sp., the study effectively illustrated a green production method for (ZnO NPs). The identified nanoparticles provided a sustainable substitute for traditional synthesis techniques and demonstrated promise for antibacterial and anticancer uses. To fully investigate their therapeutic potential and methods of action, more research is required.
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