The Role of MicroRNA-21 in Psoriasis Vulgaris

Document Type : Review Articles

Authors

1 Assistant Professor of Dermatology, Venereology and Andrology Faculty of Medicine -Benha University

2 Assistant Professor of Clinical and Chemical Pathology Faculty of Medicine, Benha University

3 Lecturer of Dermatology,Venerology and Andrology Faculty of Medicine - Benha University

4 Lecturer of Dermatology,Venereology and Andrology Faculty of Medicine - Benha University

5 Department of Dermatology, Venereology and Andrology Faculty of Medicine -Benha University

10.21608/bjas.2025.357436.1581

Abstract

Background: Psoriasis vulgaris is an immune-mediated skin disorder driven by miR-21–mediated survival of autoreactive T cells, pro-inflammatory STAT3 signaling, and keratinocyte hyperproliferation through suppression of regulatory genes such as PDCD4 and PTEN. MicroRNA-21 (miR-21), a 22-nucleotide non-coding RNA, is significantly overexpressed in psoriatic skin compared to healthy controls.
Objective: To evaluate the role of miR-21 in the diagnosis, prognosis, and therapeutic monitoring of psoriasis vulgaris.
Methods: A literature search of Medline databases (PubMed and Medscape) was conducted up to 2023. Studies were included if they were peer-reviewed, English-language articles that assessed miR-21 expression in lesional skin or blood samples (serum or plasma) of psoriasis vulgaris patients.
Study Selection: Each study was independently reviewed. Inclusion criteria required relevant assessment of miR-21 expression and clinical correlation in psoriasis vulgaris. Studies were excluded if they lacked control groups, methodological clarity, or outcome relevance.
Data Extraction and Quality Assessment: Data were independently extracted using a structured form. Studies were assessed for quality based on availability of controls, evaluation metrics, completeness of reporting, and ethical approval.
Results and Conclusion: miR-21 is consistently overexpressed in psoriatic patients and correlates positively with PASI scores, supporting its role in disease severity assessment. Its modulation following treatment suggests potential as a diagnostic and prognostic biomarker and a future therapeutic target.

Keywords

Main Subjects

Benha Journal of Applied Sciences
Volume 10, Issue 5 - Serial Number 5
Medical and Health Sciences:
May 2025
Pages 89-94

Files

Share

How to cite

Statistics