Evaluation of Efficacy of Topical Diphenylcyclopropenone in Treatment of Verrucae Vulgaris

Sadek, Dina Mahmoud; Sabry, Hanan Hassan; Mostafa Rezk, Shymaa Mostafa

doi:10.21608/bjas.2025.349884.1565

Evaluation of Efficacy of Topical Diphenylcyclopropenone in Treatment of Verrucae Vulgaris

Document Type : Original Research Papers

Authors

¹ Department of Dermatology, Andrology and Venerology Faculty of Medicine Benha University

² Professor and Head of Dermatology, Venereology and Andrology Faculty of Medicine - Benha University

³ Assistant professor of Dermatology, Venerology and Andrology Faculty of Medicine - Benha University

10.21608/bjas.2025.349884.1565

Abstract

Background: Verruca vulgaris is commonly associated with human papillomavirus (HPV) subtypes 2 and 4 and affects approximately 10% of the population. In adults, warts are less likely to resolve spontaneously and are more resistant to treatment. Moreover, immunosuppressed individuals have an increased burden of warts compared with immunocompetent patients. The first-line treatment for warts includes salicylic acid and cryotherapy; however, their efficacy rates range from 0% to 80% and 14% to 90%, respectively. objevtives:. This article aims to demonstrate efficacy and safety of contact immune sensitizers in treatment of verrucae vulgaris. Conclusions: Dinitrochlorobenzene, squaric acid dibutylester, and diphenylcyclopropenone are three substances that have demonstrated efficacy in the treatment of wart. Diphenylcyclopropenone provids a good option for the treatment of warts, and this treatment could be considered as an initial treatment option for patients who wish to avoid treatment-related pain and subsequent side effects, especially children or patients with large numbers of warts

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